Mademoiselle de Guise was born in Paris, (1615) Princess Marie de Lorraine. She lived in the Hôtel de Guise, and when her father the Duc de Guise died, she became Duchesse de Guise; but she had been known as Mademoiselle de Guise since she was a child.
The Guise family history is one of much wielding of power, brutality and sticky ends. Claiming descent from Charlemagne, the family aspired to the French throne and sought to eradicate the Bourbons. A forebear was mother of Mary Queen of Scots, another was Archbishop of Reims, another started a civil war (the War of the Three Henrys).
Mademoiselle de Guise was the last of the direct line, however, and married morganatically. This meant her several children were not heir to the title. But she had her own somewhat lavish select private court. She otherwise used her immense wealth to found a teachers’ training college, and both in Paris and her provincial lands she founded hospitals for the poor and schools for girls.
After her death in 1688 there was much wrangling over the inheritance, and the palace was sold in 1700 and became the Hôtel de Soubisse – which now houses the National Archive.